Complex Regional Pain Syndrome (CRPS) involves abnormal pain processing in both the peripheral and central nervous systems. Symptoms may include intense burning pain, swelling, temperature or color changes, stiffness, and reduced mobility. CRPS is often difficult to manage with standard pain therapies alone.

Ketamine has been used in specialized pain clinics for refractory CRPS, particularly in cases involving central sensitization and pain amplification. Ketamine infusion therapy is integrated into a comprehensive pain-management approach aimed at reducing pain severity and improving functional tolerance.