Trigeminal neuralgia is a chronic neuropathic pain condition affecting the trigeminal nerve, which provides sensation to the face. Pain episodes are often severe and may be triggered by everyday activities such as speaking, chewing, or brushing teeth. While medications such as anticonvulsants are commonly prescribed, some patients experience persistent pain or medication intolerance.

Ketamine infusion therapy is used in selected patients with treatment-resistant trigeminal neuralgia or those who are not able to tolerate conventional medication treatments to reduce abnormal nerve signaling and central sensitization.